Thermogen

AVAILABLE FOR SHIPMENT FROM MARCH 23

LOSEBiG THERMOGEN

The Science of Metabolic Activation

Metabolism isn't just about calorie numbers. It's about rate, adaptability, and the body's ability to convert energy into movement and fuel burn. When metabolic pathways are working correctly, the body doesn't store; it uses. It doesn't hold on; it consumes.

The LOSEBiG THERMOGEN it is a scientifically designed formula for thermogenic and metabolic support, based on herbal extracts, bioactive polyphenols, and micronutrients that act synergistically for:

• activation of metabolic mechanisms,
• increase in energy expenditure,
• fat burning support,
• better blood sugar and appetite control.

The Formula That Works With Your Body

• Metabolaid® Complex (Lemon Verbena & Hibiscus) – 500 mg
  Patented botanical complex studied for its action in activating AMPK, the cell's key “energy sensor.” Supports increased energy expenditure, reduced fat mass, and appetite regulation.
• Apple Cider Vinegar - 450 mg
  It contributes to the feeling of satiety and postpartum glucose regulation, helping the body avoid insulin spikes that lead to fat storage.
• Soy Lecithin – 390 mg
  Source of phospholipids involved in lipid transport, cell membrane structure, and fatty acid metabolic flow.
• Green Tea Extract (50% EGCG) – 180 mg
  The catechins in green tea enhance fatty acid oxidation and thermogenesis, increasing energy expenditure at rest and during exercise.
• Zinc Picolinate – 9 mg
  Zinc contributes to normal macronutrient metabolism and the regulation of hormones related to appetite and energy.
• Cayenne Pepper – 15 mg
  Capsaicin mildly increases thermogenesis and energy expenditure by activating calorie-burning mechanisms.
• Berberis aristata (85% Berberine) – 30 mg
  Berberine supports glucose and lipid regulation, activates AMPK, and contributes to improved metabolic response.
• White Mulberry Leaf Extract – 150 mg
  It reduces the absorption of carbohydrates from the intestine and contributes to blood sugar stabilization, limiting lipogenesis.

The Science of Synergy

LOSEBiG THERMOGEN doesn't target a single pathway but a complete metabolic system:

• Metabolism activation through AMPK (Metabolaid®, Berberine, EGCG).
  • Thermogenesis increase with capsaicin and green tea polyphenols.
  • Improvement of fatty acid burning through phospholipids and catechins.
  • Sugar & appetite regulation with apple cider vinegar and white mulberry.
  • Stable metabolic performance without stimulants and caffeine.

Daily Dosage & How to Use

• Dose: 3 capsules daily
  • Download 1 capsule in the morning, 1 capsule in the early afternoon, and 1 capsule in the evening with water
  • Duration Daily use or 12-week cycles
  • Appropriate For long-term metabolic support without nervous stimulation

Composition & Action Chart - LOSEBiG THERMOGEN

Documented Effect According to the Literature

Based on human and preclinical studies of the ingredients:

• Increased metabolic activity: ~5–10%
  • Increased fat burning ~10–17%
  • Action start time: 10–14 days of continuous use
  • Further weight loss:
  – ~2–4 kg in 8–12 weeks
  – mainly from fatty mass
  (when combined with a mild calorie deficit)

The effects vary depending on gender, age, diet, and physical activity.

Indications

• Support for metabolism and thermogenesis
  • Enhance fat tissue burning
  • Blood sugar and appetite regulation
  • Support for weight loss programs
  • Daily caffeine-free use

The Scientific Literature of LOSEBiG THERMOGEN Ingredients

1. Herranz-López M, et al.
   Lemon verbena and hibiscus polyphenol compounds help manage metabolic syndrome markers by activating AMPK.
   2019;11(2):289.
   → Documentation of AMPK activation, improvement of metabolic markers and fat mass (Metabolaid®).
2. Malagón-Ruiz J, et al.
   A botanical blend of Lippia citriodora and Hibiscus sabdariffa improves body composition in overweight subjects.
   Applied Sciences. 2024;14(9):3882.
   Reduction of fat mass and body weight in 12 weeks without lifestyle changes.
3. Kondo T, et al.
   Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects.
   Bioscience, Biotechnology, and Biochemistry. 2009;73(8):1837–1843.
   Documentation of the role of apple cider vinegar in weight and satiety management.
4. Hursel R, Westerterp-Plantenga MS.
   Catechin- and caffeine-rich teas for the control of body weight in humans.
   American Journal of Clinical Nutrition. 2013;98(6):1682S–1693S.
   Thermogenesis and increased fat oxidation through catechins (EGCG).
5. Dulloo AG, et al.
   Efficacy of green tea extract rich in catechin polyphenols and caffeine in increasing energy expenditure.
   American Journal of Clinical Nutrition. 1999;70(6):1040–1045.
   → Increased energy expenditure and fat oxidation.
6. Zhang Y, et al.
   Berberine activates AMPK and improves lipid metabolism.
   2014;63(3):360–368.
   → AMPK pathway, lipid and glucose regulation.
7. Yin J, et al.
   Efficacy of berberine in patients with metabolic disorders.
   2008;57(5):712–717.
   Clinical data for improving metabolic parameters.
8. Asano N, et al.
   Mulberry leaf extract inhibits intestinal disaccharidase activity and suppresses postprandial hyperglycemia.
   J Agric Food Chem. 2001;49(8):4208–4213.
   → Reduced carbohydrate absorption, sugar control.
9. Yoneshiro T, et al.
   Capsaicin and capsinoids increase energy expenditure by activating brown adipose tissue.
   American Journal of Clinical Nutrition. 2012;95(4):845–850.
   Thermogenesis and increased calorie burn through capsaicin.
10. Marreiro DN, et al.
    Zinc and its role in energy metabolism and appetite regulation.
    Biological Trace Element Research. 2017;179(2):1–9.
    → Role of zinc in metabolic and hormonal balance.
11. Küllenberg D, et al.
    Health effects of phospholipids in lipid metabolism.
    Lipids in Health and Disease. 2012;11:3.
    Phospholipids & lipid metabolism (lecithin).